The 4-star Polyxenia Hotel Nafplio is located 9 minutes on foot from the early 18th-century bastioned Palamidi Citadel and provides ticket service for a better travel experience. The hotel is in the Nafplio Old Town district of Nafplio, quite close to such natural sights as Bourtzi Island.

Kapodistrias Statue is 7 minutes' stroll from the accommodation, and War Museum of Nafplio is 0.6 km from it. History lovers will enjoy visiting Akronafplia Fortress (0.9 km) and Acronafplia Castle (0.7 km). This Nafplio hotel is situated very close to Tiryns Unesco-Listed Hill Fort Excavations, and KTEL Station Terminal of Argolida bus station lies 500 metres away. Polyxenia Hotel is approximately 140 km away from Kalamata Captain Vassilis Constantakopoulos airport.

All of the air-conditioned rooms are appointed with free wireless internet and a TV along with a coffeemaker and a minibar, and some of them include a balcony and a sitting area. Also, they feature wooden flooring. The private bathrooms have a separate toilet and a shower, along with comforts such as a hair dryer and bath sheets.

The Polyxenia Nafplio serves homemade breakfast in the morning. The traditional bar is also available. Situated within 300 metres of the property, the pizzeria Il Porto offers a Mediterranean menu.